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Your genes and environment play a big role. But the ratio of each is up for debate. More information Adding us as a Preferred Source in Google by using this link indicates that you would like to see more of our content in Google News results. These 1980 headshots show the cast of'Fridays,' an American late-night live comedy show, demonstrating a range of different personalities. Breakthroughs, discoveries, and DIY tips sent six days a week.

The development of deep learning approaches for modeling these multifactorial effects of GVs is still in its nascent stages, primarily due to the lack of comprehensive datasets that capture the intricate relationships between GVs and their downstream effects on complex traits.

Apennine brown bears have been isolated from their European counterparts since the Roman Empire. Breakthroughs, discoveries, and DIY tips sent every weekday. While bear attacks seem to have become a significant problem in Japan--with the country going as far as deploying the army --new research reveals that an Italian bear species has evolved to be less aggressive. Apennine brown bears () have been in close contact with humans for generations. Their small, endangered population exists only in central Italy, and previous research suggests that this population split off from other European brown bears 2,000 to 3,000 years ago .

The development of deep learning approaches for modeling these multifactorial effects of GVs is still in its nascent stages, primarily due to the lack of comprehensive datasets that capture the intricate relationships between GVs and their downstream effects on complex traits.

A timeline of genetic changes in millions of years of human evolution shows that variants linked to higher intelligence appeared most rapidly around 500,000 years ago, and were closely followed by mutations that made us more prone to mental illness. The findings suggest a "trade-off" in brain evolution between intelligence and psychiatric issues, says Ilan Libedinsky at the Center for Neurogenomics and Cognitive Research in Amsterdam, the Netherlands. Why did humans evolve big brains? "Mutations related to psychiatric disorders apparently involve part of the genome that also involves intelligence. So there's an overlap there," says Libedinsky. "[The advances in cognition] may have come at the price of making our brains more vulnerable to mental disorders."

We consider the challenging problem of estimating causal effects from purely observational data in the bi-directional Mendelian randomization (MR), where some invalid instruments, as well as unmeasured confounding, usually exist. To address this problem, most existing methods attempt to find proper valid instrumental variables (IVs) for the target causal effect by expert knowledge or by assuming that the causal model is a one-directional MR model. As such, in this paper, we first theoretically investigate the identification of the bi-directional MR from observational data. In particular, we provide necessary and sufficient conditions under which valid IV sets are correctly identified such that the bi-directional MR model is identifiable, including the causal directions of a pair of phenotypes (i.e., the treatment and outcome). Moreover, based on the identification theory, we develop a cluster fusion-like method to discover valid IV sets and estimate the causal effects of interest. We theoretically demonstrate the correctness of the proposed algorithm. Experimental results show the effectiveness of our method for estimating causal effects in both one-directional and bi-directional MR models.

In the past few years, foundation models based on large transformer networks such as Google's BERT (Kenton and Toutanova, 2019) and OpenAI's GPT family (Radford, 2018) have been shown to be invaluable aids for scientific discovery in the analysis of genomic data (Cui et al., 2024; Theodoris et al., 2023; Chen and Zou, 2025). More specifically, foundation models targeted for genomic applications typically comprise of those that are trained on enormous databases of experimental data such as scGPT (Cui et al., 2024), which was trained on transcriptomes from 33 million human cells from 441 different studies or the GeneFormer model (Theodoris et al., 2023), which was trained on 29.9 million human single-cell transcriptomes. On the other hand, foundation models based on pre-training on internet-scale databases of natural language texts may offer distinct advantages, such as potentially taking advantage of niche biological relationships which may be widely documented in scientific literature, but not necessarily be represented experimentally in large-scale genomics datasets. For this reason, some recent works have used the embedding outputs of large-language models (LLMs) such as ChatGPT (Radford, 2018) to encode the biological information contained in text-based gene descriptions, such as those in the NCBI database (Schoch et al., 2020). Notably, Chen and Zou (2025) show that these text-based gene descriptors can be input to GPT-3.5 to obtain gene embeddings that act as features/covariates for standard prediction algorithms, denoted GenePT.

At WIRED Health 2025, Orchid CEO Noor Siddiqui and the genomics pioneer George Church laid out their view of the future of genetic screening. The world of pregnancy is going to radically change, predicts Noor Siddiqui. "I think that the default way people are going to choose to have kids is via IVF and embryo screening," she said at the WIRED Health summit last week. "There's just a massive amount of risk that you can take off of the table." Siddiqui is the founder and CEO of Orchid, a biotech company that offers whole-genome screening of embryos for IVF.